咀嚼と脳の研究所

お問い合わせ
年度別研究実績

□2018年度研究実績 →
□2017年度研究実績 →
□2016年度研究実績 →
□2015年度研究実績 →
□2014年度研究実績 →

2018年度研究実績


メモ Azuma K, Toyama T, Katano M, Kajimoto K, Hayashi S, Suzuki A, Tsugane H, Iinuma M, Kubo KY. Yokukansan ameliorates hippocampus-dependent learning impairment in senescence-accelerated mouse, Biological and Pharmaceutical Bulletin, 41, 1593-1599, 2018.

メモ Azuma K, Zhou Q, Kubo KY. Morphological and molecular characterization of the senile osteoporosis in senescence-accelerated mouse prone 6 (SAMP6). Medical Molecular Morphology, 51, 139-146, 2018.

メモ Kubo KY, Kotachi M, Suzuki A, Iinuma M, Azuma K. Chewing during prenatal stress prevents prenatal stress-induced suppression of neurogenesis, anxiety-like behavior and learning deficits in mouse offspring. International Journal of Medical Science, 15, 849-58, 2018.

メモ Ono Y, Wada K, Kurata M, Seki N. Enhancement of motor-imagery ability via combined action observation and motor-imagery training with proprioceptive neurofeedback. Neuropsychologia, 114, 134-142, 2018.

メモ Tani M, Ono Y, Matsubara M, Ohmatsu S, Yukawa Y, Kohno M, Tominaga T. Action observation facilitates motor cortical activity in stroke patients with hemiplegia. Neuroscience Research, 133, 7-14, 2018.

メモ Ichinose M, Nakabayashi M, Ono Y. Sympathoexcitation constrains vasodilation in the human skeletal muscle microvasculature during post-occlusive reactive hyperemia. American Journal of Physiology - Heart and Circulatory Physiology, 315(2), H242-H253, 2018.

メモ Hirsch J, Noah JA, Zhang X, Dravida S, Ono Y. A Cross-Brain Neural Mechanism for Human-to-Human Verbal Communication. Social Cognitive and Affective Neuroscience, 13(9), 907-920, 2018.

メモ Ono Y, Esaki K, Takahashi Y, Nakabayashi M, Ichinose M, Lee KJ. Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study. Biomedical Optics Express, 9(9), 4539-4551, 2018.

メモ Onuki M, Yamamoto T, Sasaguri K, Yamada K, Okada N, Kawata T. Chewing ameliorates the effects of restraint stress on pERK-immunoreactive neurons in the rat insular cortex. Neuroscience Letters, 674: 60-65, 2018.

メモ Sasaguri K, Yamada K, Yamamoto T. Uncovering the neural circuitry involved in the stress-attenuation effects of chewing. The Japanese Dental Science Review, 54, 118-126, 2018.

2017年度研究実績


メモ Azuma K, Zhou Q, Niwa M, Kubo KY. Association between mastication, the hippocampus, and the HPA axis: a comprehensive review. International Journal of Molecular Science, 2017 Aug 3;18(8). pii: E1687. doi: 10.3390/ijms1808168718.

メモ Azuma K, Ogura M, Kondo H, Suzuki A, Hayashi S, Iinuma M, Onozuka M, Kubo KY. Maternal active mastication during prenatal stress ameliorates prenatal stress-induced lower bone mass in adult mouse offspring. International Journal of Medical Science, 14, 348-355, 2017.

メモ Kubo KY, Murabayashi C, Kotachi M, Suzuki A, Mori D, Sato Y, Onozuka M, Azuma K, Iinuma M. Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice. Archives of Oral Biology, 74, 21-27, 2017.

メモ Hirsch J, Zhang X, Noah JA, Ono Y. Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. NeuroImage, 157, 314-320, 2017.

メモ Kubota M, Ono Y, Ishiyama A, Zouridakis G, Papanicolaou A. Magnetoencephalography reveals mismatch field enhancement from unexpected syntactic category errors in English sentences. Neuroscience Letters, 662, 195-204, 2017.

メモ Nakabayashi M, Ono Y. Detection of blood flow speed in shallow and deep tissues using diffuse correlation spectroscopy. Advanced Biomedical Engineering, 6, 53-58, 2017.

メモ Sasaguri K, Yamada K, Narimatsu Y, Oonuki M, Oishi A, Koda K, Kubo KY, Yamamoto T, Kadoya T. Stress-induced galectin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes. The Journal of Physiological Science, 67, 489-496, 2017.

メモ Suzuki H, Yamada K, Matsuda Y, Onozuka M, Yamamoto T. CXCL14-like immunoreactivity exists in somatostatin-containing endocrine cells, and in the lamina propria and submucosal somatostatinergic nervous system of mouse alimentary tract. Acta Histochemica et Cytochemica, 50, 149-158, 2017.

メモ Setsu R, Hirano Y, Tokunaga M, Takahashi T, Numata N, Matsumoto K, Masuda Y, Matsuzawa D, Iyo M, Shimizu E, Nakazato M. Increased subjective distaste and altered insula activity to umami in patients with bulimia nervosa. Front Psychiatry, 8, 172, doi: 10.3389/fpsyt.2017.

メモ YamamotoY, Takahahi T, To M, Nakagawa Y, Hayashi T, Saruta J, Tsukinoki K. Continuous intake of polydextrose and lactitol combination stimulates fermentation in the cecum and salivary IgA secretion in rats. Journal of Oral Science, 59(4), 603-610, 2017.

メモ Wilson D, Keith G, Harpal B, Ram S, De Fabien M, Agnieszka W, Takahashi T. Therapy through Social Medicine: Cultivating Connections and Inspiring Solutions for Healthy Living. AIMS Medical Science, 2017, 4(2): 131-150.doi: 10.3934/medsci.2017.2.131.

メモ Tsuruta M, Takahashi T, Tokunaga M, Iwasaki M, Kataoka S, Kakuta S, Soh I, Awano S, Hirata H, Kagawa M, Ansai T. Relationships between pathologic subjective halitosis, olfactory reference syndrome, and social anxiety in young Japanese women. BMC Psychology, 2017 14;5(1):7. doi: 10.1186/s40359-017-0176-1.

2016年度研究実績


メモ Mori D, Miyake H, Mizutani K, Shimpo K, Sonoda S, Yamamoto T, Fujiwara S, Kubo KY. Effects of occlusal disharmony on the hippocampal dentate gyrus in aged senescence-accelerated mouse prone 8 (SAMP8). Archives of Oral Biology, 65, 95-101, 2016.

メモ Suzuki A, Iinuma M, Hayashi S, Sato Y, Azuma K, Kubo KY. Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring. Brain Research, 1651, 36-43, 2016.

メモ Ueda M, Li S, Itoh M, Wang MX, Hayakawa M, Islam S, Tana, Nakagawa K, Chen H, Nakagawa T. Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion. Biochemical and Biophysical Research Communications, 474, 259-63, 2016

メモ Miyake H, Mori D, Katayama T, Fujiwara S, Sato Y, Azuma K, Kubo KY. Novel stress increases hypothalamic-pituitary-adrenal activity in mice with a raised bite. Archives of Oral Biology, 68, 55-60, 2016.

メモ Kondo H, Kurahashi M, Mori D, Iinuma M, Tamura Y, Mizutani K, Shimpo K, Sonoda S, Azuma K, Kuno KY. Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment. Archives of Oral Biology, 61, 1-7, 2016.

メモ Ono Y, Saitow F, Konishi S. Differential modulation of GABAA receptors underlies postsynaptic depolarization- and purinoceptor-mediated enhancement of cerebellar inhibitory transmission: a non-stationary fluctuation analysis study. PLoS One, 11(3), e0150636, 2016.

メモ Ono Y, Ishikawa Y, Munakata M, Shibuya T, Shimada A, Miyachi H, Wake H, Tamaki K. Diagnosis of occlusal dysesthesia utilizing prefrontal hemodynamic activity with slight occlusal interference. Clinical and Experimental Dental Research, 2(2), 129-135, 2016.

メモ Teramoto S, Inaoka T, Ono Y. Regional brain activity that determines successful and unsuccessful working memory formation. Conf Proc IEEE Eng Med Biol Soc, 2016, 5550-5553, 2016.

メモ Kojo A, Yamada, K, Yamamoto T. Glucose transporter 5 (GLUT5)-like immunoreactivity is localized in subsets of neurons and glia in the rat brain. Journal of Chemical Neuroanatomy, 74, 55-70, 2016.

メモ Sasaguri K, Yamada K, Narimatsu Y, Oonuki M, Onishi A, Koda K, Kubo KY, Yamamoto T, Kadoya T. Stress-induced galactin-1 influences immune tolerance in the spleen and thymus by modulating CD45 immunoreactive lymphocytes, The Journal of Physiological Science, 10.1007/s12576-016-0478-8, 2016.

メモ Ito K, Saito Y, Yamaguchi M, Ashida K, Yamaji T, Itoh H, Takahashi T, Oda M. Addition of whey peptides to a carbohydrate-electrolyte drink enhances its effect on the early treatment of dehydration in rats. Food Science and Technology Research, 22(5), 623-629, 2016.

メモ Yamamoto Y, Takahahi T, To M, Nakagawa Y, Hayashi T, Shimizu T, Kamata Y, Saruta J, Tsukinoki K. The Salivary IgA flow rate is increased by high concentrations of short-Chain fatty acids in the cecum of rats ingesting fructooligosaccharides. Nutrients, 17, 8(8), pii: E500. doi: 10.3390/nu8080500.

2015年度研究実績


メモ Azuma K, Furuzawa M, Fujiwara S, Yamada K, Kubo KY. Effects of Active Mastication on chronic stress-induced bone loss in mice. International Journal of Medical Science, 12, 952-957, 2015.

メモ Endo S, Nishiyama A, Suyama M, Takemura M, Soda M, Chen H, Tajima K, El-Kabbani O, Bunai Y, Hara A, Matsunaga T, Ikari A. Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells. Chemico-Biological Interactions, 234, 282-289, 2015.

メモ Kurahashi M, Kondo H, Iinuma M, Tamura Y, Chen H, Kubo KY. Tooth loss early in life accelerateds age-remlated bone deterioration in mice. Tohoku Journal of Experimental Medicine, 235, 29-37, 2015.

メモ Kubo KY, Iinuma M, Chen H. Mastication as a stress-coping behavior. BioMedical Research International, 2015, 876409, 2015, doi: 10.1155/2015/876409.

メモ Chen H, Iinuma M, Onozuka M, Kubo KY. Chewing maintains hippocampus-dependent cognitive function. International Journal of Medical Science, 12, 502-509, 2015.

メモ Chen H, Senda T, Kubo KY. The osteocyte plays multiple roles in bone remodeling and mineral homeostasis. Medical Molecular Morphology, 2015 Jun;48(2):61-8. doi: 10.1007/s00795-015-0099-y.

メモ Sasaguri K, Otsuka T, Tsunashim H, Shimazaki T, Kubo KY, Onozuka M. Influence of restration adjustments on prefrontal blood flow. A simplified NIRS preliminary study. International Journal of Stomatology & Occlusion Medicine, 10.1007/s12548-015-0122-x, 2015.

メモ Matsubara M, Kayanuma H, Ono Y, Omatsu S, Tominaga T. Determination of appropriate imagery task to discriminate ERD of "pinch" and "hold" movements in healthy participants and stroke patients. Conf Proc IEEE Eng Med Biol Soc, 2015. 4598-4601, 2015.

メモ Yasuda S, Higano S, Ishiyama A, Ono Y, Kajimura I, Minamisawa S. MCG Early Detection of Pulmonary Arterial Hypertension Using Inverse Problem Analysis in Rat Model. Conf Proc IEEE Eng Med Biol Soc, 2015. 4475-4478, 2015.

メモ Tachikawa K, Izawa S, Ono Y, Kuriki S, Ishiyama A. Evaluation of the Performance to Detect Default Mode Network among Some Algorithms Applied to Resting-state fMRI Data. Conf Proc IEEE Eng Med Biol Soc, 2015. 1805-1808, 2015.

メモ Noah JA, Ono Y, Nomoto Y, Shimada S, Tachibana A, Zhang X, Bronner S, Hisch J. fMRI validation of fNIRS measurements during a naturalistic task. Journal of Visualized Experiments, 100. e52116, 2015.

メモ Ono Y, Kobayashi G, Hayama R, Ikuta R, Onozouka M, Wake H, Shimada A, Shibuya T, Tamaki K. Prefrontal hemodynamic changes associated with subjective sense of occlusal discomfort. BioMed Research International, 2015. 395705. 1-10, 2015

メモ Ono Y, Koizumi S, Onozuka M. Chewing prevents stress-induced hippocampal LTD formation and anxiety-related behaviors: a possible role of the dopaminergic system. BioMed Research International, 2015. 294068. 1-7, 2015

メモ Noah JA, Ono Y, Shimda S, Tachibana A, Bronner S. Changes in sympathetic tone during cooperative game play. Social Behavior and Personality, 43(7), 1123-1134, 2015.

メモ Yamada K, Narimatsu Y, Ono Y, Sasaguri K, Onozuka M, Kawata T, Yamamoto T. Chewing suppresses stress-induced increase of pERK immunoreactive cells in the periaqueductal grey. Neuroscience Letters, 599. 43-48, 2015.

メモ Ono Y, Noah JA, Zhang X, Nomoto Y, Suzuki T, Shimada S, Tachibana A, Bronner S, Hirsch J. Motor learning and modulation of prefrontal cortex: an fNIRS Assessment. Journal of Neural Engineering, 12(6). 066004, 2015.

メモ Ono Y, Saitow F, Konishi S. Differential modulation of GABAA receptors underlies postsynaptic depolarization- and purinoceptor-mediated enhancement of cerebellar inhibitory transmission: a non-stationary fluctuation analysis study. PLoS One, 11(3). e0150636, 2015.

メモ Yamada K, Narimatsu Y, Ono Y, Sasaguri K, Onozuka M, Kawata T, Yamamoto T. Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey. Neuroscience Letters, 599, 43-48, 2015.

メモ Suzuki H, Yamamoto T. CXCL14-like immunoreactivity exists in somatostatin-containing cells of mouse pancreas. Acta Histochemica et Cytochemica, 48, 173-178, 2015.

メモ Yamamoto Y, To M, Hayashi T, Shimizu T, Kamata Y, Saruta J, Takahashi T, Tsukinoki K. Intake of indigestible carbohydrates influences IgA response and polymeric Ig receptor expression in the rat submandibular gland. The British Journal of Nutrition, 113(12), 1895-902, 2015.

メモ Mizumoto K, Kinoshita Y, Takahashi T, Higuchi M, Bachroen C, Da Silva V. A qualitative study of risk factors related to child malnutrition in Aileu district, Timor-Leste. Asia-Pacific Journal of Public Health, 1010539513486175.

メモ Wilczynska A, Singh,M RB, Niaz A, Takahashi T, Fedeko J, De Meester F, Mondal R, Wilson DW. A modified questionnaire to find out the association of depression with increased mortality, among urban decedents, dying due to various causes. The Open Nutraceutical Journal, 8, 5-15. 2015

2014年度研究実績


メモ Onishi M, Iinuma M, Tamura Y, Kubo KY. Learning deficits and suppression of the cell proliferation in the hippocampal dentate gyrus of offspring are attenuated by maternal chewing during prenatal stress. Neuroscience Letters, 560, 77-80, 2014.

メモ Iinuma M, Kondo H, Kurahashi M, Onishi M, Tamura Y, Chen H, Kubo KY. Relationship between the early toothloss condiyion and hippocampal functional morphology. Anatomy & Physiology, 10.4172/2161-0940.1000149, 2014.

メモ Chen H, Kubo KY. Bone three-dimensional microstructural features of the common osteoporotic fracture sites. World Journal of Orthopedics, 5, 486-95, 2014.

メモ Mishiro K, Imai T, Sugitani S, Kitashoji A, Suzuki Y, Takagi T, Chen H, Oumi Y, Tsuruma K, Shimazawa M, Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS One, 9, e103818, 2014

メモ Furuzawa M, Chen H, Fujiwara S, Yamada K, Kubo KY. Chewing smeliorates chronic mild stress-induced bone loss in senescence-accelerated mouse (SAMP8), a murine model of senile osteoporosis. Experimental Gerontology, 55, 12-18, 2014.

メモ Akazaki S, Takahashi T, Nakano Y, Nishida T, Mori H, Takaoka A, Aoki H, Chen H, Kunisada T, Koike K. Three-dimensional analysis of melanosomes isolated from B16 melanoma cells by using ultra high voltage electron microscopy. Microscopy Research, 2, 1-8, 2014.

メモ Ueda M, Li S, Itoh M, Hayakawa-Yano Y, Wang MX, Hayakawa M, Hasebe-Matsubara R, Ohta K, Ohta E, Mizuno A, Matsumoto M, Chen H, Hida Y, Nakagawa T. Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax. Biochemical and Biophysical Research Communications, 443, 1232-1238, 2014

メモ Shimada J, Ueta A, Ono Y, Otsubo T. Development of a System to Measure Swallowing Motion by Surface Electromyography. Journal of St. Marianna University, 5(2), 107-115, 2014.

メモ Hristova K, Dimitrov BD, Rastogi SS, DeMeester F, Milovanovic B, Shiue I, Pella D, Chaves H, Singh RB, Takahashi T, Cheema S, Basu TK, Wilson DW, Garg M, Ozimek L, Kumar A, Cornelissen G, Petrov I, Buttar HS, Handjiev S. Prevention strategies for cardiovascular diseases and diabetes mellitus in developing countries: World Conference of Clinical Nutrition 2013. Nutrition 30, 1085-11089, DOI: doi.org/10.1016/j.nut.2013.12.013.

メモ Fedacko J, Singh RB, Gupta A, Hristova K, Toda E, Kumar A, Saxena M, Baby A, Singh R, Takahashi T, Wilson DW. Inflammatory mediators in chronic heart failure in North India. Acta Cardiologica, 69, 391-398, 2014.

咀嚼と脳の研究所 Institute for Mastication and Brain Sciense(IMBS)

   


関連ホームページ
明治大学理工学部電気電子生命学科健康医工学研究室
産業医科大学